At least two Fine Gael Senators are likely to lose the party whip when the first Seanad vote on abortion legislation takes place later.
Paul Bradford and Fidelma Healy Eames have been vocal opponents of the Protection of Life During Pregnancy Bill.
Others are uncertain, with Michael Mullins another possibility to revolt this evening
Five Fine Gael TDs lost the whip over the legislation - including European Affairs Minister Lucinda Creighton.