The construction of the new National Children's hospital may experience significant delays, as a result of the covid-19 crisis.
Its building contractor BAM says the current public health restrictions will also lead to additional costs on a once-off and ongoing basis.
The project is currently estimated to cost more than €1.7 billion.
Work has not resumed at the Dublin site since the Covid 19 lockdown was eased.
BAM had anticipated the project would require more than 2,000 people on-site at peak building time, however, due to public health restrictions, less than half of that number could safely be deployed.
The contractor believes it is unfair that they should shoulder the cost burden resulting from the health measures.
CEO of Children in Hospital Ireland, Anna Gunning, says the €1.7 billion project needs to be built as soon as possible.
Ms Gunning says "As long as this very long debate over the children's hospital has been going on, we've always felt 'Just get it built and make sure we have the state of the art facilities we need for our children and young people.'"