Two out of three girls availed of the HPV vaccine when offered to them in school last year, which is around 2,300 pupils.
As a result of the uptake last year, 126 of those girls will be spared a cervical cancer diagnosis, while 42 of those lives will be saved.
Cervical cancer kills 90 women in Ireland every year, almost two women every week.
Today is International HPV Awareness Day and the Irish Cancer Society is urging parents and students to get the jab.
In September the vaccine is being extended to boys and it's hoped more lives will be saved as a result.
The Irish Cancer Society says 'Those who said no to the vaccine in autumn now have a chance to change their mind. We encourage them to seek credible information about this vaccine. It is really important parents base their decisions on medical advice and scientific evidence and don’t allow themselves to be misled by dangerous and discredited anti-vaccination myths on social media.'